CandidatesPreclinicalPhase 1Phase 2Phase 3reg. filingmarketed
Tivozanib (RCC)
VEGFR TKI
TIVO - 1
TIVO - 3
TiNivo
Tivozanib (HCC)
VEGFR TKI
Deductive
Ficlatuzumab
Anti-HGF/c-MET IgG1 mAb
HNSCC
Pancreatic
AML
AV-203 (CAN017)
Anti-ERBB3 mAb
Oncology
AV-380
Anti-GDF15 IgG1 mAb
Cachexia
AV-353
Anti-Notch 3 mAb
Oncology
Tivozanib (RCC)
VEGFR TKI
TIVO - 1 marketed
TIVO - 3 marketed
TiNivo Phase 2
Tivozanib (HCC)
VEGFR TKI
Deductive Phase 2
Ficlatuzumab
Anti-HGF/c-MET IgG1 mAb
HNSCC Phase 2
Pancreatic Phase 2
AML Phase 2
AV-203 (CAN017)
Anti-ERBB3 mAb
Oncology Phase 1
AV-380
Anti-GDF15 IgG1 mAb
Cachexia Phase 1
AV-353
Anti-Notch 3 mAb
Oncology Preclinical

AVEO is an oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for cancer patients. AVEO’s strategy is to focus its resources toward development and commercialization of its product candidates in North America, while leveraging partnerships to support development and commercialization in other geographies. AVEO’s lead candidate, FOTIVDA® (tivozanib), received U.S. Food and Drug Administration (FDA) approval in March 2021 for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. FOTIVDA was approved in August 2017 in the European Union and other countries in the territory of its partner EUSA Pharma for the treatment of adult patients with advanced RCC. AVEO has previously reported promising early clinical data on ficlatuzumab (Anti-HGF c-MET IgG1 mAb) in head and neck cancer, acute myeloid leukemia and pancreatic cancer and is conducting a randomized Phase 2 confirmatory clinical trial of ficlatuzumab in head and neck cancer. AVEO’s earlier-stage pipeline includes several monoclonal antibodies in oncology development, including AV-203 (Anti-ERBB3 mAb), AV-380 (Anti-GDF15 IgG1 mAb) and AV-353 (Anti-Notch 3 mAb). AVEO is committed to creating an environment of diversity and inclusion as a foundation for innovation.

FOTIVDA® (tivozanib) is an oral, once-daily, differentiated vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI). It is a potent, selective inhibitor of VEGFRs 1, 2, and 3 with a long half-life designed to improve efficacy and tolerability.1,2 

For more information, please visit FOTIVDA

Ficlatuzumab, AV-203, AV-380 and AV-353 are investigational drugs and have not yet been approved by the U.S. Food and Drug Administration (FDA).

1Fotivda (Tivozanib) SmPC August 2017
2Motzer RJ, Nosov D, Eisen T, et al. J Clin Oncol 2013; 31(30): 3791-9

Focused on Patients. Driven by Science.