Press Release

CORRECTION – AVEO Oncology Announces Appointment of Chief Medical Officer and Formation of Scientific Advisory Committee

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– Industry veteran brings extensive clinical development experience to AVEO Oncology leadership
team as Chief Medical Officer –

– Formation of a Scientific Advisory Committee from world-renowned cancer institutions –

BOSTON, March 28, 2024 (GLOBE NEWSWIRE) — In a release issued under the same headline on March 25 by AVEO Pharmaceuticals, the text in the second paragraph has been corrected to better reflect Dr. Braendle’s clinical research experience. The corrected release follows:

AVEO Oncology (“AVEO”), an LG Chem company, today announced the appointment of Edgar E. Braendle, MD, PhD as AVEO Oncology’s new Chief Medical Officer. Dr. Braendle is a life sciences executive with experience spanning from early drug discovery to the launch of small molecules, biologics, radiopharmaceuticals, gene and cell therapies, and medical device development.

Dr. Braendle brings more than twenty years of clinical research experience to AVEO Oncology, most recently serving as Chief Development Officer of Autolus Therapeutics Plc since July 2021, where he was responsible for all development functions and the conduct of a pivotal program in CD-19 directed genetically modified autologous T cell immunotherapy for adult acute lymphoblastic leukemia, and the respective filing to the U.S. Food & Drug Administration and European Medicines Agency.

“We are delighted to have Dr. Braendle join the AVEO Oncology team particularly at this important juncture as we seek to become a global top 20 oncology leader,” said Michael P. Bailey, President and Chief Executive Officer of AVEO Oncology, an LG Chem company. “Dr. Braendle’s significant experience will be instrumental in our efforts to develop and diversify our pipeline.”

Prior to his time at Autolus, Dr. Braendle held the role of Executive Vice President, Chief Medical Officer and Global Head of Development at Sumitomo Dainippon Pharma Oncology, where he was responsible for a full range of development functions and progressed several early-stage, first in human programs and late-stage programs. Prior to this, Dr. Braendle served as President and CEO of ARUP Laboratories, a national clinical and anatomic reference laboratory. Dr. Braendle also spent over a decade at Novartis AG, where he served as Senior Vice President and Global Head of Companion Diagnostics and led the company’s precision medicine approach. Dr. Braendle received his medical degree at RWTH Aachen University in Germany, followed by specialty training in medical oncology, urology and pharmacology. Dr. Braendle is also an associate professor at the University of Ulm, Germany.

Today, AVEO Oncology, an LG Chem company, and LG Chem Life Sciences also announced the formation of its Scientific Advisory Committee (“Committee”). This esteemed group of experts in oncology research and clinical development were selected to advise and bring unique perspectives to AVEO and LG Chem’s clinical strategy and business development initiatives. “We are excited and privileged to have the opportunity to work with this group of top oncology experts to help guide our drug development initiatives from discovery through commercialization. Notably, the Committee represents key areas of interest including gastrointestinal, genitourinary, ovarian, lung and head and neck cancers,” said Mr. Bailey.

The Scientific Advisory Committee is comprised of several leading cancer experts, including:

Al B. Benson III, MD, FACP, FACCC, FASCO
Professor of Medicine
Associate Director from Cooperative Groups
Robert H. Lurie Comprehensive Cancer
Center of Northwestern University

Scott Kopetz, MD, PhD
Professor and Deputy Chair for Translational
Research, Department of Gastrointestinal
Medical Oncology
Division of Cancer Medicine
University of Texas MD Anderson Cancer
Center

D. Ross Camidge, MD, PhD
Professor of Medicine/ Oncology
Joyce Zeff Chair in Lung Cancer
Director, Thoracic Oncology
Faculty, Developmental Therapeutics
Program
University of Colorado Cancer Center, Aurora

John L. Marshall, MD
Chief, Hematology and Oncology
Professor of Medicine and Oncology
Director, Otto J Ruesch Center for the Cure
of Gastrointestinal Cancers Georgetown
Lombardi Comprehensive Cancer Center

Edward Chu, MD, MMS
Director, Montefiore Einstein Cancer Center
Albert Einstein College of Medicine

Tony S.K. Mok, BBS, FASCO
Chairman, Department of Clinical Oncology
LiShu Fan Professor of Clinical Oncology
The Chinese University of Hong Kong

Ezra Cohen, MD, FRCPSC, FASCO
Chief Medical Officer of Oncology
Tempus
University of California- San Diego

Paul G. Richardson, MD
Director, Clinical Research
Jerome Lipper Multiple Myeloma Center
Dana-Farber Cancer Institute

Kevin J. Cullen, MD
Professor of Oncology
University of Maryland Marlene and Stewart
Greenebaum Comprehensive Cancer Center
University of Maryland School of Medicine

Joseph Tabernero, MD, PhD
Head, Medical Oncology Department
Director, Vall d’Hebron Institute of Oncology
Professor of Medicine, UVic-UCC

Enrique Grande, MD, PhD, Msc
Director, Medical Oncology Program and
Clinical Research lead
MD Anderson Cancer Center Madrid

Jan Vermorken, MD, PhD
Emeritus Professor of Oncology
Department of Medical Oncology
Antwerp University Hospital

About AVEO Pharmaceuticals, Inc.
AVEO is an oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for patients with cancer. AVEO currently markets FOTIVDA® (tivozanib) in the U.S. for the treatment of adult patients with relapsed or refractory renal cell carcinoma (RCC) following two or more prior systemic therapies. AVEO continues to develop FOTIVDA in immunooncology and other novel targeted combinations in RCC and other indications, and has other investigational programs in clinical development. AVEO became a wholly owned subsidiary of LG Chem Life Sciences USA, Inc. on January 19, 2023. AVEO continues to operate under the AVEO Oncology, an LG Chem company, name. For more information, please visit www.aveooncology.com.

About LG Chem, Ltd. and LG Chem Life Sciences
LG Chem, Ltd. (LG Chem) is a leading global chemical company with a diversified business portfolio in the key areas of petrochemicals, advanced materials, and life sciences. The company manufactures a wide range of products from high-value added petrochemicals to renewable plastics, specializing in cutting-edge electronic and battery materials, as well as drugs and vaccines to deliver differentiated solutions for its customers. LG Chem Life Sciences develops, manufactures, and globally commercializes pharmaceutical products, with a focus on Oncology, Immunology, and Metabolic diseases. Our mission is to transform people’s lives through inspiring science and leading innovation. For more information, please visit www.lgchem.com.

Contacts Media:
John F. Kouten
JFK Communications, Inc.
jfkouten@jfkhealth.com
(908) 227-4714
Source: AVEO Pharmaceuticals, Inc.

AVEO Oncology Announces Publication of Long-Term Survival in Patients With Relapsed/Refractory Advanced Renal Cell Carcinoma Treated With Tivozanib: Analysis of the Phase III TIVO-3 Trial in The Oncologist

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BOSTON, Feb. 06, 2024 (GLOBE NEWSWIRE) — AVEO Oncology, an LG Chem company (“AVEO”), today announced The Oncologist has published a post-hoc analysis of long-term progression free survival, overall survival and safety data from the Phase 3 TIVO-3 trial evaluating FOTIVDA® (tivozanib) in patients with relapsed or refractory (R/R) advanced renal cell carcinoma (RCC). In the publication, FOTIVDA demonstrated a consistent safety profile and a long-term survival benefit in patients who were alive and progression-free at 12 months, suggesting a durable clinical benefit and safety across age groups regardless of prior treatment.

“The post-hoc analysis from TIVO-3 provides additional evidence supporting the clinical utility of tivozanib in the third- or fourth-line refractory setting in patients with advanced renal cell carcinoma,” said lead author Kathryn E. Beckermann, MD, PhD, Assistant Professor of Medicine in the Division of Hematology Oncology at Vanderbilt-Ingram Cancer Center. “The results suggest there is a clinically meaningful population of patients who can experience a long-term survival benefit from tivozanib over sorafenib.”

TIVO-3 compared the efficacy and safety of the vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) FOTIVDA and sorafenib (Nexavar®) in patients with R/R advanced RCC whose disease progressed with two or three prior systemic therapies. The trial included a predefined subgroup of patients (26%) who were previously treated with both an immuno-oncology (IO) therapy and a VEGFR TKI.

The post hoc analysis showed investigator-assessed landmark long-term progression-free survival (PFS) rates were higher with FOTIVDA compared to sorafenib (3 years: 12.3% vs. 2.4%; 4 years: 7.6% vs. 0%). After 22.8 months mean follow-up, the overall survival (OS) hazard ratio (HR) for FOTIVDA was 0.89 (95% confidence interval [CI]: 0.70-1.14); when conditioned on a clinically meaningful 12-month PFS time point, FOTIVDA showed significant improvement in OS compared to sorafenib (HR: 0.45; 95% CI: 0.22-0.91; 2-sided P = 0.0221). Mean time on treatment was 11.0 months with FOTIVDA and 6.3 months with sorafenib. There were fewer treatment-related adverse events (TRAEs) and lower dose modification rates with FOTIVDA than with sorafenib as well as fewer grade ≥3 TRAEs on FOTIVDA (46%) than sorafenib (55%). Dose modification rates were lower with FOTIVDA than with sorafenib across age and prior IO subgroups; and prior IO therapy did not impact dose reductions or discontinuations in either arm.

The advent of targeted therapies and IO therapies is considered a major advancement in the treatment of RCC, and IO-based combination therapy is the frontline standard of care for patients with advanced RCC who require systemic therapy.4 However, despite the demonstrated benefits of IO combination therapies, most patients with RCC ultimately experience disease progression and require subsequent treatments5, underscoring the need for safe, tolerable and effective therapies in the refractory setting.

“For patients with relapsed or refractory advanced renal cell carcinoma, long-term progression-free survival is a vital measure of the value of anticancer therapy,” commented Michael Bailey, President and CEO of AVEO Oncology. “The long term PFS analysis combined with the post hoc conditional survival analysis is especially encouraging in this highly refractory population, as it builds upon the previously reported PFS advantage for FOTIVDA over sorafenib, a non-selective VEGFR TKI.”

Study Details

TIVO-3 was a Phase 3, global, open-label, parallel-arm study comparing the safety and efficacy of FOTIVDA versus sorafenib in patients with R/R advanced RCC whose disease progressed with two or three prior VEGFR TKI systemic regimens. The trial randomized 350 patients to receive FOTIVDA (1.5 mg once daily) or sorafenib (400 mg twice daily). The intent-to-treat (ITT) population included 175 patients in each arm; the safety population included 173 patients in the FOTIVDA arm and 170 in the sorafenib arm.

About FOTIVDA® (tivozanib)

FOTIVDA® (tivozanib) is an oral, next-generation vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI). It is a potent, selective inhibitor of VEGFRs 1, 2, and 3 with a long half-life designed to improve efficacy and tolerability. AVEO received U.S. Food and Drug Administration (FDA) approval for FOTIVDA on March 10, 2021, for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies, based on data from the TIVO-3 trial comparing FOTIVDA to sorafenib. FOTIVDA was approved in August 2017 in the European Union and other countries in the territory of its partner EUSA Pharma (UK) Limited for the treatment of adult patients with advanced RCC. FOTIVDA has been shown to significantly reduce regulatory T-cell production in preclinical models.6 FOTIVDA was discovered by Kyowa Kirin.

IMPORTANT SAFETY INFORMATION

WARNINGS AND PRECAUTION

Hypertension and Hypertensive Crisis: Control blood pressure prior to initiating FOTIVDA. Monitor for hypertension and treat as needed. For persistent hypertension despite use of anti-hypertensive medications, reduce the FOTIVDA dose.

Cardiac Failure: Monitor for signs or symptoms of cardiac failure throughout treatment with FOTIVDA.

Cardiac Ischemia and Arterial Thromboembolic Events: Closely monitor patients who are at increased risk for these events. Permanently discontinue FOTIVDA for severe arterial thromboembolic events, such as myocardial infarction and stroke.

Venous Thromboembolic Events: Closely monitor patients who are at increased risk for these events. Permanently discontinue FOTIVDA for severe venous thromboembolic events.

Hemorrhagic Events: Closely monitor patients who are at risk for or who have a history of bleeding. Proteinuria: Monitor throughout treatment with FOTIVDA. For moderate to severe proteinuria, reduce the dose or temporarily interrupt treatment with FOTIVDA.

Thyroid Dysfunction: Monitor before initiation and throughout treatment with FOTIVDA.

Risk of Impaired Wound Healing: Withhold FOTIVDA for at least 24 days before elective surgery. Do not administer for at least 2 weeks following major surgery and adequate wound healing. The safety of resumption of FOTIVDA after resolution of wound healing complications has not been established.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Discontinue FOTIVDA if signs or symptoms of RPLS occur.

Embryo-Fetal Toxicity: Can cause fetal harm. Advise patients of the potential risk to a fetus and to use effective contraception.

Allergic Reactions to Tartrazine: The 0.89 mg capsule of FOTIVDA contains FD&C Yellow No.5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible patients.

ADVERSE REACTIONS

The most common (≥20%) adverse reactions were fatigue, hypertension, diarrhea, decreased appetite, nausea, dysphonia, hypothyroidism, cough, and stomatitis, and the most common Grade 3 or 4 laboratory abnormalities (≥5%) were sodium decreased, lipase increased, and phosphate decreased.

DRUG INTERACTIONS

Strong CYP3A4 Inducers: Avoid coadministration of FOTIVDA with strong CYP3A4 inducers.

USE IN SPECIFIC POPULATIONS

Lactation: Advise not to breastfeed.
Females and Males of Reproductive Potential: Can impair fertility.
Hepatic Impairment: Adjust dosage in patients with moderate hepatic impairment. Avoid use in patients with severe hepatic impairment.

To report SUSPECTED ADVERSE REACTIONS, contact AVEO Pharmaceuticals, Inc. at 1-833-FOTIVDA (1-833-368-4832) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see FOTIVDA Full Prescribing Information which is available at www.AVEOoncology.com.

About AVEO Pharmaceuticals, Inc.
AVEO is an oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for patients with cancer. AVEO currently markets FOTIVDA® (tivozanib) in the U.S. for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. AVEO continues to develop FOTIVDA in immuno-oncology and other novel targeted combinations in RCC and other indications, and has other investigational programs in clinical development. AVEO became a wholly owned subsidiary of LG Chem Life Sciences USA, Inc. on January 19, 2023. AVEO continues to operate under the AVEO Oncology, an LG Chem company, name.

About LG Chem, Ltd. and LG Chem Life Sciences
LG Chem, Ltd. (LG Chem) is a leading global chemical company with a diversified business portfolio in the key areas of petrochemicals, advanced materials, and life sciences. The company manufactures a wide range of products from high-value added petrochemicals to renewable plastics, specializing in cutting-edge electronic and battery materials, as well as drugs and vaccines to deliver differentiated solutions for its customers. LG Chem Life Sciences develops, manufactures, and globally commercializes pharmaceutical products, with a focus on Oncology, Immunology, and Metabolic diseases. Our mission is to transform people’s lives through inspiring science and leading innovation. For more information, please visit www.lgchem.com

References
American Cancer Society. Cancer Facts & Figures 2024. Atlanta: American Cancer Society; 2024. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2024-cancer-factsfigures.html.
2 Tran J. Ornstein MC. Clinical review on the management of metastatic renal cell carcinoma. JCO Oncol Pract. 2021;18(3):187-196. https://ascopubs.org/doi/10.1200/OP.21.00419.
3 Bergstrom A, Hsieh CC, Lindblad P, et al. Obesity and renal cell cancer – a quantitative review. Br J Cancer. 2001;85(7):984-990. https://www.nature.com/articles/6692040.
4 Tenold M, Ravi P, Kumar M, et al. Current approaches to the treatment of advanced or metastatic renal cell carcinoma. Am Soc Clin Oncol Educ Book. 2020;40:1-10. https://ascopubs.org/doi/10.1200/EDBK_279881.
5 Vento JA, Rini BI. Treatment of refractory metastatic renal cell carcinoma. Cancers (Basel). 2022;14(20):5005. doi: 10.3390/cancers14205005.
6 Pawlowski N, Hoerzer H, Singh-Jasuja H, Hilf N. Impact of various first- and second-generation tyrosine-kinase inhibitors on frequency and functionality of immune cells. Cancer Res. 2013;78(8_Suppl):3971. https://aacrjournals.org/cancerres/article/73/8_Supplement/3971/589572/Abstract-3971-Impact-ofvarious-
first-and-second
.

Contacts

Media:
John F. Kouten
JFK Communications, Inc.
jfkouten@jfkhealth.com
(609) 241-7352

Son Junil / Kim Junam
lgchempr@lgchem.com

Source: AVEO Pharmaceuticals, Inc.

AVEO Oncology Enrolls First Patient in Pivotal FIERCE-HN Clinical Trial to Evaluate Ficlatuzumab in Combination with ERBITUX® (cetuximab) in Patients with HPV-negative Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

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  • Phase 3 Registrational Trial Seeks to Improve Survival Outcomes in Underserved HPVnegative R/M Head and Neck Cancer Patient Population
  • Trial Launch Follows FDA Fast Track Designation of Ficlatuzumab/cetuximab Combination for Treatment of Relapsed/Recurrent HNSCC

BOSTON, Jan. 16, 2024 (GLOBE NEWSWIRE) — AVEO Oncology (“AVEO”), an LG Chem company, today announced enrollment of the first patient in the FIERCE-HN trial, a global, multicenter, randomized, double-blind, placebo-controlled, phase 3 clinical trial evaluating ficlatuzumab in combination with ERBITUX® (cetuximab), an anti-EGFR antibody, in patients with human papillomavirus (HPV)-negative recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). Ficlatuzumab is AVEO’s investigational antibody that targets hepatocyte growth factor (HGF).

“The start of enrollment for the pivotal FIERCE-HN trial is an important milestone in the advancement of the combination of ficlatuzumab and cetuximab, as it brings us a step closer to offering a new potential therapy to a patient population that has limited effective treatment options available to them today,” said Michael Bailey, president and chief executive officer of AVEO Oncology. “We are excited about the potential to extend the survival for this population of cancer patients where a significant unmet need currently exists.”

The U.S. Food and Drug Administration designated the investigation of ficlatuzumab and ERBITUX® (cetuximab) a Fast Track development program for relapsed/recurrent HNSCC in September 2021. That designation followed AVEO’s June 2021 announcement of positive results from a randomized phase 2 study of ficlatuzumab alone or in combination with cetuximab in patients with pan-refractory, metastatic HNSCC. In that study, patients with HPV-negative disease, a subgroup normally associated with poorer outcomes, who received the ficlatuzumab and cetuximab combination demonstrated an overall response rate of 38% versus 0% in the HPV positive subgroup, including 13% of HPV-negative patients with complete responses.

“Despite the advent of immune checkpoint inhibitor therapy for recurrent and metastatic head and neck squamous cell carcinoma, few patients with advanced disease survive for longer than one year,” commented Julie E. Bauman, MD, MPH, director of the George Washington Cancer Center as well as associate dean of cancer and professor of medicine at the George Washington School of Medicine & Health Sciences. “We therefore approach the FIERCE-HN trial with a mix of urgency and optimism, as the combination of ficlatuzumab and cetuximab has the potential to expand the range of viable therapeutic options for this underserved population.”

About the FIERCE-HN Trial
The FIclatuzumab in combination with ERBITUX® (cetuximab) Clinical Evaluation in Head and Neck cancer patients (FIERCE-HN trial) is designed to initially compare the efficacy and safety of two dose levels of ficlatuzumab plus cetuximab and then will proceed to a registrational stage to compare the optimal dose level to a control arm of placebo plus cetuximab in participants with HPV-negative R/M HNSCC. The trial is open to adults with a primary diagnosis of R/M HNSCC. Eligible participants must have failed prior therapy with an anti-programmed cell death protein 1, also known as PD-1, or programmed cell death ligand 1, also known as PD-L1, immune checkpoint inhibitor and with platinum-based chemotherapy, administered in combination or sequentially. Failure of prior treatment may be due to disease progression or intolerance to treatment. The primary FIERCE-HN endpoint is overall survival. Secondary endpoints include progression-free survival, objective response rate, duration of response, safety and tolerability, and pharmacokinetics of the ficlatuzumab and cetuximab combination. AVEO aims to enroll 410 participants across the clinical trial’s three arms. For more details about the clinical trial, please visit clinicaltrials.gov (NCT06064877) or the FIERCE-HN trial website at www.fiercehn.com.

About Ficlatuzumab
Ficlatuzumab (formerly known as AV-299) is a potent hepatocyte growth factor (HGF) immunoglobulin G1 inhibitory antibody that binds to the HGF ligand with high affinity and specificity. HGF is the natural ligand of c-Met and blocking HGF inhibits signaling through the HGF/c-Met signaling pathway. The U.S. Food and Drug Administration designated as a Fast Track development program the investigation of ficlatuzumab and ERBITUX® (cetuximab) for relapsed/recurrent HNSCC in September 2021.

ERBITUX is a registered trademark owned by or licensed to Eli Lilly and Company, its subsidiaries, or affiliates.

About AVEO Pharmaceuticals, Inc.
AVEO is an oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for patients with cancer. AVEO currently markets FOTIVDA® (tivozanib) in the U.S. for the treatment of adult patients with relapsed or refractory renal cell carcinoma (RCC) following two or more prior systemic therapies. AVEO continues to develop FOTIVDA in immunooncology and other novel targeted combinations in RCC and other indications, and has other investigational programs in clinical development. AVEO became a wholly owned subsidiary of LG Chem Life Sciences Innovation Center, Inc. on January 19, 2023. AVEO continues to operate under the AVEO Oncology, an LG Chem company, name. For more information, please visit www.aveooncology.com.

About LG Chem, Ltd. and LG Chem Life Sciences
LG Chem, Ltd. (LG Chem) is a leading global chemical company with a diversified business portfolio in the key areas of petrochemicals, advanced materials, and life sciences. The company manufactures a wide range of products from high-value added petrochemicals to renewable plastics, specializing in cutting-edge electronic and battery materials, as well as drugs and vaccines to deliver differentiated solutions for its customers. LG Chem Life Sciences develops, manufactures, and globally commercializes pharmaceutical products, with a focus on Oncology, Immunology, and Metabolic diseases. Our mission is to transform people’s lives through inspiring science and leading
innovation. For more information, please visit www.lgchem.com.

Contacts

Media:
John F. Kouten
JFK Communications, Inc.
jfkouten@jfkhealth.com
(908) 227-4714

Source: AVEO Pharmaceuticals, Inc.

AVEO Oncology, an LG Chem company, Earns Spot on Boston Globe’s 2023 Top Places to Work List for Second Consecutive Year

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Boston, MA (November 30, 2023) — For the second year in a row, AVEO Oncology, an LG Chem company, has earned a spot on the Boston Globe’s annual ‘Top Places to Work in Massachusetts’ list.  AVEO Oncology appears in the medium-sized company (100-249 employees) category.

“We are incredibly excited to be selected once again as one of Massachusetts’ ‘Top Places to Work’,” said Michael Bailey, President and CEO, AVEO Oncology.  “This recognition is particularly gratifying as it occurred after the acquisition of AVEO by LG Chem, a time that can be the most difficult transition for a company. I could not be more proud of the AVEO team for their continued pursuit of the patient-focused mission and vision and I couldn’t be more thankful for the LG Chem team for working so hard to ensure a smooth integration of the two companies.”

In October 2022, LG Chem announced it would acquire AVEO Oncology, and the deal officially closed in January 2023. Together, AVEO and LG Chem have a shared mission and vision to provide innovative solutions to improve cancer patients’ lives and to become a global leader in the oncology therapeutics market.

Top firms are selected for the Boston Globe’s prestigious ‘Top Places to Work’ list based on anonymous employee surveys about leadership, appreciation, benefits, corporate social responsibility and more.  Nearly 100,000 employees participated in the survey from over 380 companies.

In addition to a shared mission regarding oncology drug development, AVEO and LG Chem share a culture of community service.  At an all-employee meeting earlier this year, employees from both companies assembled and packed emergency kits to benefit southwest Florida residents affected by Hurricane Ian. AVEO is also passionate about giving back to the local community and is proud to have been the top corporate fundraiser for The Jimmy Fund and the Boston Red Sox’s “Strike Out Cancer” initiative for the last two years. This fundraiser supports patient care and revolutionary cancer research at Dana Farber Cancer Institute — causes that resonate closely with AVEO’s mission.

Other company core values include “most respectful interpretation” which fosters honest and collaborative communication, a sense of thoughtful urgency, integrity, goal orientation, and encouraging an engaging work environment. The personification of these core principles enhances AVEO’s vibrant, unified and purpose-driven corporate culture, which has been further validated by the Boston Globe’s ‘Top Places to Work’ recognition for a second year in a row.

“In my years with AVEO Oncology I have been privileged to participate in a common mission to help improve the lives of cancer patients and their families,” said Katie McCarthy, Sr. Manager, Marketing, AVEO Oncology.  “And, while our mission is extremely serious, we find time to have fun.”

In the wake of the global pandemic, coupled with an integration, the needs of AVEO’s employees have changed.  “We recognize this and have worked hard to provide flexibility, improved benefits, and an even greater sense of purpose,” said Deb Wall, Director, Human Resources, AVEO Oncology.  “It’s more than just managing remote versus in-office or hybrid working conditions – we understand that our employees need more – more flexibility, more support, and a direct connection to our patients and our mission.  These elements unquestionably make AVEO a top place to work.”

About AVEO Pharmaceuticals, Inc.
AVEO is an oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for patients with cancer. AVEO currently markets FOTIVDA® (tivozanib) in the U.S. for the treatment of adult patients with relapsed or refractory renal cell carcinoma (RCC) following two or more prior systemic therapies. AVEO continues to develop FOTIVDA in immuno-oncology and other novel targeted combinations in RCC and other indications, and has other investigational programs in clinical development. AVEO became a wholly owned subsidiary of LG Chem Life Sciences Innovation Center, Inc. on January 19, 2023. AVEO continues to operate under the AVEO Oncology, an LG Chem company, name.

Contacts

Media:
John F. Kouten
JFK Communications, Inc.
jfkouten@jfkhealth.com
(609) 241-7352

AVEO_LG-Chem_Logo

Source: AVEO Pharmaceuticals, Inc.